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## Various toxicities and compassionate use: 2 case reports In a report, a 3-year-old girl and an 8-year-old girl were described, who developed haemoptysis, desaturation or bronchiolitis obliterans organising pneumonia during compassionate use of nebulised cidofovir for recurrent laryngeal papillomatosis (RLP). Case 1: A 3-year-old girl, who had a history of orotracheal intubation and prematurity at birth, was diagnosed with RLP due to human papillomavirus (HPV)-6 at the age of 9 months. Three months after the diagnosis, she underwent a tracheostomy. After the diagnosis, she underwent monthly surgical interventions for resection of the lesions, and also received adjuvant therapy with interferon-α, intralesional cidofovir, indole-3-carbinol [3-indolcarbinol] and human-papillomavirus vaccine recombinant quadrivalent Merck [Gardasil]. At the age of 3 years, a papillomatous injury was observed in the right main bronchus during fibrobronchoscopy. She was stared on compassionate treatment with nebulised cidofovir 4mL (concentration of 10 mg/mL) three times per week. After the fifth dose of nebulised cidofovir, she presented with frank haemoptysis and desaturation. Hence, she was hospital

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Publisher

Adis International Limited (now part of Wolters Kluwer Health); Springer-Verlag; Springer Science and Business Media LLC (ISSN 0114-9954)

Published

2020

Language

EN

Field

Medicine (Health Sciences)