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This study investigated the bronchodilator mechanisms of Vitex negundo, a plant traditionally used for respiratory disorders. Intravenous administration of a crude extract from V. negundo leaves dose-dependently relaxed carbachol-induced bronchoconstriction in rats, similar to the reference drug aminophylline. In isolated guinea pig trachea, the extract relaxed contractions induced by carbachol and high potassium concentrations, suggesting it acts through phosphodiesterase inhibition and calcium channel blo

Author

jp fernandez

Language

EN