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Peripheral neuropathy in Parkinson’s disease by Dion A. Paul; Abdul Rehman M. Qureshi; Abdul Qayyum Rana is a Medicine article available to read on EtoBox.

What is Peripheral neuropathy in Parkinson’s disease about?

Peripheral neuropathy (PN) is a common neurological problem defined as a dysfunction of sensory, motor, and autonomic nerves. The presence of peripheral neuropathy has recently been noticed in Parkinson's disease (PD) This comorbidity is concerning as it increases the burden on patients whose motor functions are previously compromised. A comprehensive computer-based literature review utilizing multiple peer-reviewed databases (e.g., Embase, PsycINFO, CINAHL, etc.) was conducted. There is evidence for the utility of robust diagnostic criteria to distinguish between large fiber neuropathy (LFN) and small fiber neuropathy (SFN). Some studies have established links between prolonged L-DOPA exposure and prevalence with increased levels of homocysteine (HCY) and methylmalonic acid (MMA) as pathological underlying mechanisms. PN in PD patients with relatively truncated exposure to L-DOPA therapy may have underlying mutations in the Parkin and MHTFR gene or separate mitochondrial disorders. Vitamin B12 and cobalamin deficiencies have also been implicated as drivers of PN. Accumulation of phosphorylated α-synuclein is another central feature in PN and deems urgent exploration via large coho

Who reads Peripheral neuropathy in Parkinson’s disease?

Author

Dion A. Paul; Abdul Rehman M. Qureshi; Abdul Qayyum Rana

Publisher

Springer Milan; Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1590-1874)

Published

2020

Language

EN

Field

Medicine (Health Sciences)