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GENetic and clinical Predictors Of treatment response in Depression: the GenPod randomised trial protocol by Laura Thomas; Jean Mulligan; Victoria Mason; Debbie Tallon; Nicola Wiles; Philip Cowen; David Nutt; Michael O'Donovan; Deborah Sharp; Tim Peters; Glyn Lewis is a Medicine article available to read on EtoBox.

What is GENetic and clinical Predictors Of treatment response in Depression: the GenPod randomised trial protocol about?

## Background The most effective pharmacological treatments for depression inhibit the transporters that reuptake serotonin (Selective Serotonin Reuptake Inhibitors – SSRIs) and noradrenaline (Noradrenaline Reuptake Inhibitors – NaRIs) into the presynaptic terminal. There is evidence to suggest that noradrenaline and serotonin enhancing drugs work through separate mechanisms to produce their clinical antidepressant action. Although most of the current evidence suggests there is little difference in overall efficacy between SSRIs and NaRIs, there are patients who respond to one class of compounds and not another. This suggests that treatment response could be predicted by genetic and/or clinical characteristics. Firstly, this study aims to investigate the influence of a polymorphism (SLC6A4) in the 5HT transporter in altering response to SSRI medication. Secondly, the study will investigate whether those with more severe depression have a better response to NaRIs than SSRIs. ## Methods/design The GenPod trial is a multi-centre randomised controlled trial. GPs referred patients aged between 18–74 years presenting with a new episode of depression, who did not have any medical contrain

Who reads GENetic and clinical Predictors Of treatment response in Depression: the GenPod randomised trial protocol?

Author

Laura Thomas; Jean Mulligan; Victoria Mason; Debbie Tallon; Nicola Wiles; Philip Cowen; David Nutt; Michael O'Donovan; Deborah Sharp; Tim Peters; Glyn Lewis

Publisher

BioMed Central; Springer (Biomed Central Ltd.); Current Controlled Trials Ltd.; [London]: BioMed Central, 2006-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1468-6708)

Published

2008

Language

EN

Field

Medicine (Health Sciences)