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Can I read Safety and Efficacy of Topiramate in Individuals With Cryptogenic Sensory Peripheral Neuropathy With Metabolic Syndrome: The TopCSPN Randomized Clinical Trial on EtoBox?
Safety and Efficacy of Topiramate in Individuals With Cryptogenic Sensory Peripheral Neuropathy With Metabolic Syndrome: The TopCSPN Randomized Clinical Trial by A. Gordon Smith; J. Robinson Singleton; Adrienne Aperghis; Christopher S. Coffey; Peter Creigh; Merit Cudkowicz; Robin Conwit; Dixie Ecklund; Janel K. Fedler; Anna Gudjonsdottir; Peter Hauer; David N. Herrmann; Marianne Kearney; John Kissel; Elizabeth Klingner; Adam Quick; Cathy Revere; Amro Stino; Elias Sirja; Aaron Vinik; Amanda Peltier; Mamatha Pasnoor; Brian Callaghan; Daniella Maria Menichella; Chris Nance; Reza Seyedsadiadi; Mario Saporta; Lauren Phillips; Eroboghene Ubogu; Shawn Bird; Stefanie Geisler; Glenn Lopate; James Caress; Thomas Brannagan; Kelly Gwathmey; Erik Ortega; Tahseen Mozaffar; Mark Milstein; Dianna Quan; Janet Snowden; Julie Charles; Elizabeth Wood; Joan Mountain; Christine Annis; Debra Guntrum; Cynthia Gibson; Noreen Connolly; Steffen Behrens-Spraggins; Mariana Doudova; Candice Dolan; Amy Bartlett; Julie Agriesti; Carolina Casellini; Michael Bailey; Kelly Lowen; Tricia McKinney; Sally Furukawa; Alyssa Lackey; Tina Liu; Katheryn Jennens; Samantha Colgan; Amanda Rasnake; Meghan Stelzer; Courtney Graft; Tina Ward; Taylor Coffey; Cosette Burian; Monika Szela; Justine Houseman; Connie Casale; Jeri Sieren; Heena Olalde; Nicole Kressin; Loriane Brenner; Peter James; Claudia Maria Brito Pires; Natalie Grant; Wendy Levy; Julie Steele; Maria Paredes; Steven Hopkins; Amruta Joshi; William Thayer; Amy Conger; Jovana Valdez; Melanie Benge; Elizabeth Harders; Kelsey Moulton; Mengesha Teshome; Nikki Bauer; Kelly Streckfuss; Summer Harris; Jessyca Clemons; Karie Bond; Arreum Kim; Raisy Fayerman; Johana Gonzalez; Joyce Moran; Pranay Vissa; Bridget Wilkins; Nicole Turcotte; Stephanie Strong; Isela Hernandez; Marie Wencel; Diana Moyer; Melanie Meton; Elena Slabbekoorn; Rehana Rafi; Diane Capobianco; Connie Parido; NeuroNEXT NN108 TopCSPN Study Team is a Medicine article available to read on EtoBox.
What is Safety and Efficacy of Topiramate in Individuals With Cryptogenic Sensory Peripheral Neuropathy With Metabolic Syndrome: The TopCSPN Randomized Clinical Trial about?
## Importance Cryptogenic sensory peripheral neuropathy (CSPN) is highly prevalent and often disabling due to neuropathic pain. Metabolic syndrome and its components increase neuropathy risk. Diet and exercise have shown promise but are limited by poor adherence. ## Objective To determine whether topiramate can slow decline in intraepidermal nerve fiber density (IENFD) and/or neuropathy-specific quality of life measured using the Norfolk Quality of Life–Diabetic Neuropathy (NQOL-DN) scale. ## Design, Setting, and Participants Topiramate as a Disease-Modifying Therapy for CSPN (TopCSPN) was a double-blind, placebo-controlled, randomized clinical trial conducted between February 2018 and October 2021. TopCSPN was performed at 20 sites in the National Institutes of Health–funded Network for Excellence in Neurosciences Clinical Trials (NeuroNEXT). Individuals with CSPN and metabolic syndrome aged 18 to 80 years were screened and randomly assigned by body mass index (<30 vs ≥30), which is calculated as weight in kilograms divided by height in meters squared. Patients were excluded if they had poorly controlled diabetes, prior topiramate treatment, recurrent nephrolithiasis, type 1 diabe
Who reads Safety and Efficacy of Topiramate in Individuals With Cryptogenic Sensory Peripheral Neuropathy With Metabolic Syndrome: The TopCSPN Randomized Clinical Trial?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- A. Gordon Smith; J. Robinson Singleton; Adrienne Aperghis; Christopher S. Coffey; Peter Creigh; Merit Cudkowicz; Robin Conwit; Dixie Ecklund; Janel K. Fedler; Anna Gudjonsdottir; Peter Hauer; David N. Herrmann; Marianne Kearney; John Kissel; Elizabeth Klingner; Adam Quick; Cathy Revere; Amro Stino; Elias Sirja; Aaron Vinik; Amanda Peltier; Mamatha Pasnoor; Brian Callaghan; Daniella Maria Menichella; Chris Nance; Reza Seyedsadiadi; Mario Saporta; Lauren Phillips; Eroboghene Ubogu; Shawn Bird; Stefanie Geisler; Glenn Lopate; James Caress; Thomas Brannagan; Kelly Gwathmey; Erik Ortega; Tahseen Mozaffar; Mark Milstein; Dianna Quan; Janet Snowden; Julie Charles; Elizabeth Wood; Joan Mountain; Christine Annis; Debra Guntrum; Cynthia Gibson; Noreen Connolly; Steffen Behrens-Spraggins; Mariana Doudova; Candice Dolan; Amy Bartlett; Julie Agriesti; Carolina Casellini; Michael Bailey; Kelly Lowen; Tricia McKinney; Sally Furukawa; Alyssa Lackey; Tina Liu; Katheryn Jennens; Samantha Colgan; Amanda Rasnake; Meghan Stelzer; Courtney Graft; Tina Ward; Taylor Coffey; Cosette Burian; Monika Szela; Justine Houseman; Connie Casale; Jeri Sieren; Heena Olalde; Nicole Kressin; Loriane Brenner; Peter James; Claudia Maria Brito Pires; Natalie Grant; Wendy Levy; Julie Steele; Maria Paredes; Steven Hopkins; Amruta Joshi; William Thayer; Amy Conger; Jovana Valdez; Melanie Benge; Elizabeth Harders; Kelsey Moulton; Mengesha Teshome; Nikki Bauer; Kelly Streckfuss; Summer Harris; Jessyca Clemons; Karie Bond; Arreum Kim; Raisy Fayerman; Johana Gonzalez; Joyce Moran; Pranay Vissa; Bridget Wilkins; Nicole Turcotte; Stephanie Strong; Isela Hernandez; Marie Wencel; Diana Moyer; Melanie Meton; Elena Slabbekoorn; Rehana Rafi; Diane Capobianco; Connie Parido; NeuroNEXT NN108 TopCSPN Study Team
- Publisher
- American Medical Association (AMA)
- Published
- 2023
- Field
- Medicine (Health Sciences)