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Decreased expression of APAF-1 and increased expression of cathepsin B in invasive pituitary adenoma by Cristiana Tanase; Radu Albulescu; Elena Codrici; Bogdan Calenic; Ionela Daniela Popescu; Simona Mihai; Laura Necula; Maria Linda Cruceru; Mihail Eugen Hinescu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Decreased expression of APAF-1 and increased expression of cathepsin B in invasive pituitary adenoma about?
## Purpose Apoptotic protease-activating factor-1 (APAF-1) and cathepsin B are important functional proteins in apoptosis; the former is involved in the intrinsic (mitochondrial) pathway, while the latter is associated with both intrinsic and extrinsic pathways. Changes in the expression of apoptosome-related proteins could be useful indicators of tumor development since a priori defects in the mitochondrial pathway might facilitate the inception and progression of human neoplasms. Our aim was to evaluate the profiles of APAF-1 and cathepsin B in relation with other molecules involved in apoptosis/proliferation and to correlate them with the aggressive behavior of invasive pituitary adenomas. ## Materials and methods APAF-1 and cathepsin B were assessed in tissue samples from 30 patients with pituitary adenomas, of which 16 were functional adenomas and 22 were invasive adenomas. ## Results A positive relationship between high proliferation and invasiveness was observed in invasive pituitary adenomas when compared to their noninvasive counterparts (Ki-67 labeling index – 4.72% versus 1.75%). Decreased expression of APAF-1 was recorded in most of the invasive adenomas with a high pro
Who reads Decreased expression of APAF-1 and increased expression of cathepsin B in invasive pituitary adenoma?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Cristiana Tanase; Radu Albulescu; Elena Codrici; Bogdan Calenic; Ionela Daniela Popescu; Simona Mihai; Laura Necula; Maria Linda Cruceru; Mihail Eugen Hinescu
- Publisher
- Dove Press Ltd.; Dove Medical Press; Dove Medical Press Ltd; [Auckland N.Z.]: Dove Medical Press, c2008-; Informa UK Limited; Dove Medical Press Ltd. (ISSN 1178-6930)
- Published
- 2014
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)