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GIP-dependent adrenal Cushing's syndrome with incomplete suppression of ACTH by Ronald J. M. Croughs; Pierre M. J. Zelissen; Theo J. M. V. Van Vroonhoven; Leo J. Hofland; Nina N'diaye; André Lacroix; Wouter W. De Herder is a Medicine article available to read on EtoBox.

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ACTH‐independent Cushing's syndrome may be due to the development of ectopic hormone receptors in adrenal tissue. Thus, in food‐dependent Cushing's syndrome the adrenals aberrantly express receptors for gastric inhibitory polypeptide (GIP). We present the case of a 60‐year‐old woman with food‐dependent Cushing's syndrome whose cortisol levels increased after stimulation with CRH. In this patient with Cushing's syndrome the finding of low basal plasma cortisol levels in the late night and early morning as well as a paradoxical rise of plasma cortisol during a 7‐h infusion with dexamethasone (carried out without any restriction in food intake), suggested that cortisol production was stimulated at times of food intake. Hourly measurements of plasma cortisol for 48 h revealed prominent meal‐related peaks. A plasma cortisol response, elicited by oral glucose administration, could be prevented by octreotide. Plasma ACTH was low or undetectable. CRH administration was followed by a ACTH response from 3 to 16 ng/l and a plasma cortisol response from 230 to 680 nmol/l. Octreotide treatment for nearly five months induced a partial clinical and biochemical remission. Total bilateral adrenalec

Who reads GIP-dependent adrenal Cushing's syndrome with incomplete suppression of ACTH?

Author

Ronald J. M. Croughs; Pierre M. J. Zelissen; Theo J. M. V. Van Vroonhoven; Leo J. Hofland; Nina N'diaye; André Lacroix; Wouter W. De Herder

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)

Published

2000

Language

EN

Field

Medicine (Health Sciences)