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Synthesis, Anticancer Activity and Mitochondrial Mediated Apoptosis Inducing Ability of 2,5-Diaryloxadiazole–pyrrolobenzodiazepine Conjugates by Ahmed Kamal; D. Dastagiri; M. Janaki Ramaiah; E. Vijaya Bharathi; J. Surendranadha Reddy; G. Balakishan; Pranjal Sarma; S.N.C.V.L. Pushpavalli; Manika Pal-Bhadra; Aarti Juvekar; Subrata Sen; Surekha Zingde is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Synthesis, Anticancer Activity and Mitochondrial Mediated Apoptosis Inducing Ability of 2,5-Diaryloxadiazole–pyrrolobenzodiazepine Conjugates about?

A series of 2,5-diaryloxadiazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates have been prepared and evaluated for their anticancer activity. These conjugates have shown promising activity with GI 50 values ranging from <0.1 to 0.29 lV. It is observed that some of these conjugates particularly 4a, 4d, 4i and 4l exhibit significant anticancer activity. Some detailed biological assays relating to the cell cycle aspects associated to Bax and caspases have been examined with a view to understand the mechanism of action of these conjugates.

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Author

Ahmed Kamal; D. Dastagiri; M. Janaki Ramaiah; E. Vijaya Bharathi; J. Surendranadha Reddy; G. Balakishan; Pranjal Sarma; S.N.C.V.L. Pushpavalli; Manika Pal-Bhadra; Aarti Juvekar; Subrata Sen; Surekha Zingde

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)