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Immunologically reactive M. leprae antigens with relevance to diagnosis and vaccine development by Lucas H Sampaio; Mariane MA Stefani; Regiane M Oliveira; Ana LM Sousa; Greg C Ireton; Steven G Reed; Malcolm S Duthie is a Medicine article available to read on EtoBox.
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## Background Leprosy is a chronic infectious disease caused by __Mycobacterium leprae__ that can manifest a wide variety of immunological and clinical outcomes ranging from potent humoral responses among borderline lepromatous (BL) and lepromatous (LL) patients to strong cellular responses among tuberculoid (TT) and borderline tuberculoid (BT) patients. Until recently, relatively little has been known about the immune responses to individual proteins of __M. leprae__ recognized during leprosy. ## Methods The immune reactivity to a panel of 33 __M. leprae__ recombinant proteins was evaluated among leprosy patients and controls from a high endemic area for leprosy (Goiania/GO, Central Brazil). Serum IgG responses were measured by ELISA (45 participants/group) and T cell responses (20 participants/group) were evaluated by IFN-gamma production in 24 hours whole blood cultures with antigen (whole blood assay-WBA). Study groups were newly diagnosed, untreated TT/BT and BL/LL leprosy patients classified by Ridley Jopling criteria and household contacts of BL/LL patients (HHC). Control groups were HIV-1 negative pulmonary tuberculosis patients (TB) and healthy individuals from the same en
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- Author
- Lucas H Sampaio; Mariane MA Stefani; Regiane M Oliveira; Ana LM Sousa; Greg C Ireton; Steven G Reed; Malcolm S Duthie
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2334)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)