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with GVHD, including subclinical restrictive syndrome in 2 cases and recurrent spontaneous pneumothorax in 1 child. No patient showed clinical thyroid symptoms, while 7 patients (17%) developed compensated primary hypothyroidism. Growth impairment occurred in 9 patients (21%) in terms of height velocity reduction, while 6 patients (14%) developed primary ipogonadism. In one patient a brain tumor was reported as a second neoplasm. Ocular complications, mainly cataract, occurred in 11 patients (26%). In univariate and multivariate analysis, pulmonary complications were statistically increased by GVHD vs no. Cataract occurred less frequently, although at a not significant level due to the small number of patients, with hyperfractionated TBI (1/10 among Group A patients) than with fractionated TBI (10/32 among Group B patients). No differences were observed regarding age, sex, status at the time of BMT, conditioning chemotherapy regimen and previous cranial irradiation (6 patients). Conclusion: TBI has taken an important part in the conditioning regimen before BMT in childhood ALL. This retrospective study showed that long term complications of TBI are not symptomatic in most children

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Author

E.C. Halperin; F. Laurie; T.J. Fitzgerald

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2001

Language

EN

Field

Medicine (Health Sciences)