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Systematic Review and Meta-analysis: Gene Association Studies in Neonatal Sepsis by Daniel Swarr; Megha Sharma; C. Cotten; Haresh Kirpalani; Lakshmi Srinivasan is a Medicine article available to read on EtoBox.

What is Systematic Review and Meta-analysis: Gene Association Studies in Neonatal Sepsis about?

Association studies of various gene variants in neonatal sepsis show conflicting results. We performed a systematic review of candidate gene association studies in neonatal sepsis to provide pooled estimates of risk for selected gene variants. We performed a search using MeSH terms "infection," "sepsis," "infant," "genetic variation," "polymorphism," and "genetic association studies." We included studies evaluating associations between neonatal sepsis and genetic variants (2000-2015). We excluded case reports/series, commentaries, narrative reviews, and nonhuman research. We assessed quality of studies using STREGA guidelines. Following estimation of odds ratios (ORs), data were pooled using random effects models. Twenty eight of 1,404 identified studies were included. Meta-analyses were performed for interleukin (IL)-6, tumor necrosis factor-α (TNF-α), and IL-10 as these gene variants were tested in multiple studies. TNF-α 308GG genotype demonstrated trends toward increased sepsis risk in the primary analysis of culture-proven sepsis (OR 1.18, 95% confidence interval [CI] 0.97-1.44). IL-10 1082GG genotype was associated with lower sepsis odds in very low-birth-weight (VLBW) inf

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Author

Daniel Swarr; Megha Sharma; C. Cotten; Haresh Kirpalani; Lakshmi Srinivasan

Publisher

Georg Thieme Verlag KG

Published

2016

Language

EN

Field

Medicine (Health Sciences)