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Soluble RAGE as a severity marker in community acquired pneumonia associated sepsis by Rodrigo M Narvaez-Rivera; Adrian Rendon; Mario C Salinas-Carmona; Adrian G Rosas-Taraco is a Medicine article available to read on EtoBox.

What is Soluble RAGE as a severity marker in community acquired pneumonia associated sepsis about?

## Background Community-acquired pneumonia (CAP) is considered the most important cause of death from infectious disease in developed countries. Severity assessment scores partially address the difficulties in identifying high-risk patients. A lack of specific and valid pathophysiologic severity markers affect early and effective sepsis therapy. HMGB-1, sRAGE and RAGE have been involved in sepsis and their potential as severity markers has been proposed. The aim of this study was to evaluate HMGB-1, RAGE and sRAGE levels in patients with CAP-associated sepsis and determine their possible association with clinical outcome. ## Method We evaluated 33 patients with CAP-associated sepsis admitted to the emergency room and followed in the medical wards. Severity assessment scores (CURB-65, PSI, APACHE II, SOFA) and serologic markers (HMGB-1, RAGE, sRAGE) were evaluated on admission. ## Results Thirty patients with a diagnosis of CAP-associated sepsis were enrolled in the study within 24 hours after admission. Fourteen (46.6%) had pandemic (H1N1) influenza A virus, 2 (6.6%) had seasonal influenza A and 14 other diagnoses. Of the patients in the study group, 16 (53.3%) had a fatal outcome.

Who reads Soluble RAGE as a severity marker in community acquired pneumonia associated sepsis?

Author

Rodrigo M Narvaez-Rivera; Adrian Rendon; Mario C Salinas-Carmona; Adrian G Rosas-Taraco

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2334)

Published

2012

Language

EN

Field

Medicine (Health Sciences)