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Influence of the mouse hepatitis virus (MHV) infection on the growth of human tumors in the athymic mouse by Andreas P. Kyriazis; Linda Dipersio; J. Gabriel Michael; Amadeo J. Pesce is a Medicine article available to read on EtoBox.

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## Abstract The growth characteristics and histological appearance of tumors resulting from transplantation of the tumor lines HEp‐2 and SW480 into pathogen‐free and mouse hepatitis virus infected athymic mice were studied. Subcutaneous or intra‐peritoneal implantation 1 × 10^6^ neoplastic cells into pathogen‐free animals resulted in tumor growth. Subcutaneous transplants grew locally, surrounded by a capsule of connective tissue. The fibrovascular stroma supporting the neoplastic tissue was minimal and infiltration of tumor capsule was observed. Intraperitoneal tumors grew in a multifocal pattern, were not encapsulated, showed marked invasiveness and metastasized. The same number of neoplastic cells (1×10^6^) transplanted into hepatitis‐positive animals failed to develop into grossly visible tumors. When the number of transplanted cells was increased to 2×10^7^, tumors appeared in a few animals. All tumors, regardless of the site of transplantation, were characterized by the presence of severe fibrohistiocytic reaction at the site of implantation that possibly influenced the tumor growth. No evidence supporting T‐cell‐mediated tumor rejection was observed. It is concluded that the

Who reads Influence of the mouse hepatitis virus (MHV) infection on the growth of human tumors in the athymic mouse?

Author

Andreas P. Kyriazis; Linda Dipersio; J. Gabriel Michael; Amadeo J. Pesce

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1979

Language

EN

Field

Medicine (Health Sciences)