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Can I read Complementary Base Pairing and the Origin of Substitution Mutations on EtoBox?
Complementary Base Pairing and the Origin of Substitution Mutations by Michael D. Topal; Jacques R. Fresco is a Physics and Astronomy article available to read on EtoBox.
What is Complementary Base Pairing and the Origin of Substitution Mutations about?
On the basis of chemical considerations and model building, the Watson-Crick concept of complementary base pairing is extended to a wider range of DNA pairs that A-T and G-C (including A-C, G-T, A-A, G-G and G-A) by invoking imino or enol tautomers (or protonated species) and synisomers. The virtual absence of these additional base pairs from DNA is explained in terms of the low frequency with which these unfavoured forms occur and the two-step mechanism of DNA synthesis, whereby residues are first incorporated by the DNA polymerase and then checked. This base-pairing hypothesis is used to explain the origin, nature and level of spontaneous substitution mutations, their enhancement by base analogues, and the unique effects of certain mutator alleles.
Who reads Complementary Base Pairing and the Origin of Substitution Mutations?
It is typically read by researchers, students, and practitioners in Physics and Astronomy.
- Author
- Michael D. Topal; Jacques R. Fresco
- Publisher
- Springer Science and Business Media LLC
- Published
- 1976
- Language
- EN
- Field
- Physics and Astronomy (Physical Sciences)