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Current Practice and Future Directions for Optimization of Platelet Transfusions in Patients with Severe Therapy-induced Cytopenia by Torunn O. Apelseth; Tor Hervig; Øystein Bruserud is a Medicine article available to read on EtoBox.

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## l e i n f o Platelet transfusions are mainly used for patients with thrombocytopenia due to bone marrow failure, especially cancer patients developing severe chemotherapy-induced thrombocytopenia (e.g. patients with acute leukemia or other hematologic malignancies). A prophylactic transfusion strategy is now generally accepted in developed countries. Some clinical data, however, support the use of a therapeutic transfusion strategy at least for certain subsets of these patients. Several methodological approaches can then be used to evaluate the outcome of platelet transfusions, including peripheral blood platelet increments and bleeding assessments. Several factors will influence the efficiency of platelet transfusions; fever and ongoing hemorrhage are among the most important patient-dependent factors, but the number and quality of the transfused platelets are also important. The quality of transfused platelets can be evaluated by analyzing platelet activation, metabolism or senescence/apoptosis. Only evaluation of metabolism is included in international guidelines, but high-throughput methods for evaluation of activation and senescence/apoptosis are available and should be inc

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Author

Torunn O. Apelseth; Tor Hervig; Øystein Bruserud

Publisher

Elsevier Science; Elsevier ; Churchill Livingstone; Elsevier BV (ISSN 0268-960X)

Published

2011

Language

EN

Field

Medicine (Health Sciences)