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Can I read Synthesis and Stereochemical Determination of Diunsaturated Valproic Acid Analogs Including Its Major Diunsaturated Metabolite. on EtoBox?
Synthesis and Stereochemical Determination of Diunsaturated Valproic Acid Analogs Including Its Major Diunsaturated Metabolite. by A Acheampong; F S Abbott is a Medicine article available to read on EtoBox.
What is Synthesis and Stereochemical Determination of Diunsaturated Valproic Acid Analogs Including Its Major Diunsaturated Metabolite. about?
Valproic acid, an antiepileptic drug, is transformed into diunsaturated metabolites in humans. Synthesis of the geometric isomers of 2-(1'-propenyl)-2-pentenoic acid and 2-(1'-propenyl)-3-pentenoic acid was attempted using known procedures. The final product, a mixture of isomers, was converted into tert-butyldimethylsilyl or ethyl derivatives. Capillary gas-liquid chromatography-mass spectrometry analysis of the derivatives showed at least three isomeric dienoic acids from synthesized products. Argentation thin-layer chromatography was effective in resolving the isomeric mixture into a single isomer or mixture of two isomers. Thin-layer chromatography and gas-liquid chromatography retention data, photochemical isomerization studies, and nuclear magnetic resonance spectrometry were used to characterize the dienoic acids. By comparison of the retention times of the diunsaturated metabolites with synthesized reference compounds, the structure assigned to the major diunsaturated metabolite is 2-[(E)-1'-propenyl](E)-2-pentenoic acid.
Who reads Synthesis and Stereochemical Determination of Diunsaturated Valproic Acid Analogs Including Its Major Diunsaturated Metabolite.?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- A Acheampong; F S Abbott
- Publisher
- Elsevier BV
- Published
- 1985
- Language
- EN
- Field
- Medicine (Health Sciences)