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Regenerative abnormalities in Notophthalmus viridescens induced by repeated amputations by G. E. Dearlove; M. H. Dresden is a Environmental Science article available to read on EtoBox.

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## Abstract The fidelity of the regenerative response in the adult newt, __Notophthalmus viridescens__, was examined following repeated amputations at the level of the distal one‐third of humerus. Three to four months following amputation, all regenerates were scored for gross morphology, reamputated, and stained with methylene blue for skeletal elements. The occurrence of abnormal regeneration with respect both to gross morphology and to skeletal structure was found to increase directly with the number of times the limb stumps were required to initiate dedifferentiation and repair. The initial amputation‐regeneration process produced structurally normal replacement limbs in 91% of the cases examined. Reamputations of 4‐digit regenerates (3‐4 months after the previous transection) resulted in structurally abnormal regenerates in 28% of the cases following two amputation; 50% of the cases following three amputations; 65% of the cases following four amputations; and 81% of the cases following five amputations. The relationship between repeated dedifferentiation, proliferation, and redifferentiation and normal limb development are discussed.

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Author

G. E. Dearlove; M. H. Dresden

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-104X)

Published

1976

Language

EN

Field

Environmental Science (Life Sciences)