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Localization of serotonin 5-HT2 receptors in living human brain by positron emission tomography using N1-([11C]-methyl)-2-BR-LSD by Dean F. Wong; John R. Lever; Paul R. Hartig; Robert F. Dannals; Victor Villemagne; Beth J. Hoffman; Alan A. Wilson; Hayden T. Ravert; Jonathan M. Links; Ursula Scheffel; Henry N. Wagner Jr. is a Neuroscience article available to read on EtoBox.
What is Localization of serotonin 5-HT2 receptors in living human brain by positron emission tomography using N1-([11C]-methyl)-2-BR-LSD about?
## N1-(111C]-Methyl>2-Br-LSD ([llC] -MBL) has been developed as a positron emission tomography (PET) imaging agent for serotonin 5-HT2 receptors. In vitro receptor binding assays with nonradioactive MBL show high-affinity binding to serotonin 5-HT2 receptors (Ki = 0.5 nM), a secondary interaction of 8-fold lower affinity with dopamine D2 receptors, and low-affinity interactions with al-adrenergic as well as serotonin 5-HT1 receptors. Intravenous injection of [llC]-MBL in a baboon led to selective labeling of cortical regions that was markedly blocked by prior administration of ketanserin, a selective 5-HT2 receptor antagonist. Clinical trials with [llC]-MBL have been conducted in seven normal human volunteers, and the regional distribution of radioactivity in the brain was distinctly serotonergic. Labeling was highest in frontal, temporal, and parietal cortex with lower levels observed in caudate and putamen. The tracer rapidly washed from the cerebellum and the low levels of activity in this brain region were used to define nonspecific binding. The maximum specificity was reached between 30 and 60 minutes postinjection when frontal cortex to cerebellum ratios ranged from 1.7 for a
Who reads Localization of serotonin 5-HT2 receptors in living human brain by positron emission tomography using N1-([11C]-methyl)-2-BR-LSD?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Dean F. Wong; John R. Lever; Paul R. Hartig; Robert F. Dannals; Victor Villemagne; Beth J. Hoffman; Alan A. Wilson; Hayden T. Ravert; Jonathan M. Links; Ursula Scheffel; Henry N. Wagner Jr.
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)
- Published
- 1986
- Language
- EN
- Field
- Neuroscience (Life Sciences)