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Is Mandible Derived Mesenchymal Stromal Cells Superior in Proliferation and Regeneration to Long Bone-derived Mesenchymal Stromal Cells? by Madhan Jeyaraman; Tushar Verma; Naveen Jeyaraman; Bishnu Prasad Patro; Arulkumar Nallakumarasamy; Manish Khanna is a Medicine article available to read on EtoBox.
What is Is Mandible Derived Mesenchymal Stromal Cells Superior in Proliferation and Regeneration to Long Bone-derived Mesenchymal Stromal Cells? about?
Mesenchymal stromal cells (MSCs) are cells with the characteristic ability of self-renewal along with the ability to exhibit multilineage differentiation. Bone marrow (BM) is the first tissue in which MSCs were identified and BM-MSCs are most commonly used among various MSCs in clinical settings. MSCs can stimulate and promote osseous regeneration. Due to the difference in the development of long bones and craniofacial bones, the mandibular-derived MSCs (M-MSCs) have distinct differentiation characteristics as compared to that of long bones. Both mandibular and long bone-derived MSCs are positive for MSC-associated markers such as CD-73, -105, and -106, stage-specific embryonic antigen 4 and Octamer-4, and negative for hematopoietic markers such as CD-14, -34, and -45. As the M-MSCs are derived from neural crest cells, they have embryogenic cells which promote bone repair and high osteogenic potential. __In vitro__ and __in vivo__ animal-based studies demonstrate a higher rate of proliferation and high osteogenic potential for M-MSCs as compared to long-bones MSCs, but __in vivo__ studies in human subjects are lacking. The BM-MSCs have their advantages and limitations. M-MSCs may b
Who reads Is Mandible Derived Mesenchymal Stromal Cells Superior in Proliferation and Regeneration to Long Bone-derived Mesenchymal Stromal Cells??
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Madhan Jeyaraman; Tushar Verma; Naveen Jeyaraman; Bishnu Prasad Patro; Arulkumar Nallakumarasamy; Manish Khanna
- Publisher
- Baishideng Publishing Group Inc
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)