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Chemical-Shift-Encoded Magnetic Resonance Imaging and Spectroscopy to Reveal Immediate and Long-Term Multi-Organs Composition Changes of a 14-Days Periodic Fasting Intervention: A Technological and Case Report by Viallon, Magalie; Leporq, Benjamin; Drinda, Stephan; Wilhelmi de Toledo, Françoise; Galusca, Bogdan; Ratiney, Helene; Croisille, Pierre is a Medicine article available to read on EtoBox.

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The aim of this study was to investigate the feasibility of measuring the effects of a 14-day Periodic Fasting (PF) intervention (<200 cal) on multi-organs of primary interest (liver, visceral/subcutaneous/bone marrow fat, muscle) using non-invasive advanced magnetic resonance spectroscopic (MRS) and imaging (MRI) methods. One subject participated in a 14-day PF under daily supervision of nurses and specialized physicians, ingesting a highly reduced intake: 200 Kcal/day coupled with active walking and drinking at least 3 L of liquids/day. The fasting was preceded by a 7-day pre-fasting vegetarian period and followed by 14 days of stepwise reintroduction of food. The longitudinal study collected imaging and biological data before the fast, at peak fasting, and 7 days, 1 month, and 4 months after re-feeding. Body fat mass in the trunk, abdomen, and thigh, liver and muscle mass, were respectively computed using advanced MRI and MRS signal modeling. Fat fraction, MRI relativity index T2 and susceptibility (Chi), as well as Fatty acid composition, were calculated at all-time points. A decrease in body weight (BW: -9.5%), quadriceps muscle volume (-3.2%), Subcutaneous and Visceral Adipos

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Author

Viallon, Magalie; Leporq, Benjamin; Drinda, Stephan; Wilhelmi de Toledo, Françoise; Galusca, Bogdan; Ratiney, Helene; Croisille, Pierre

Publisher

Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2014- (ISSN 2296-861X)

Published

2019

Language

EN

Field

Medicine (Health Sciences)