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Simultaneous Age‐related Depolarization of Mitochondrial Membrane Potential and Increased Mitochondrial Reactive Oxygen Species Production Correlate with Age‐related Glutamate Excitotoxicity in Rat Hippocampal Neurons by Mordhwaj S. Parihar; Gregory J. Brewer is a Neuroscience article available to read on EtoBox.
What is Simultaneous Age‐related Depolarization of Mitochondrial Membrane Potential and Increased Mitochondrial Reactive Oxygen Species Production Correlate with Age‐related Glutamate Excitotoxicity in Rat Hippocampal Neurons about?
## Abstract Mitochondria are implicated in glutamate excitotoxicity by causing bioenergetic collapse, loss of Ca^2+^ homeostasis, and generation of reactive oxygen species (ROS), all of which become increasingly important clinically with age. Little is known about how aging affects the relative importance of mitochondrial membrane potential (ΔΨ~m~) and ROS production. To determine aging affects on ΔΨ~m~ and ROS production in individual somal and axonal/dendritic mitochondria, we compared ROS production while simultaneously monitoring ΔΨ~m~ before and after glutamate treatment of live neurons from embryonic (day 18), middle‐aged (9–12 months), and old (24 months) rats. At rest, old neuronal mitochondria 1) showed a higher rate of ROS production that was particularly strong in axonal/dendritic mitochondria relative to that in middle‐age neurons, 2) were more depolarized in comparison with neurons of other ages, and 3) showed no differences in ROS or ΔΨ~m~ as a function of distance from the nucleus. All ΔΨ~m~ grouped into three classes of high (less than –120 mV), medium (–85 to –120 mV), and low (greater than –85 mV) polarization that shifted toward the lower classes with age at rest
Who reads Simultaneous Age‐related Depolarization of Mitochondrial Membrane Potential and Increased Mitochondrial Reactive Oxygen Species Production Correlate with Age‐related Glutamate Excitotoxicity in Rat Hippocampal Neurons?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Mordhwaj S. Parihar; Gregory J. Brewer
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 2007
- Language
- EN
- Field
- Neuroscience (Life Sciences)