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Postoperative intensity‐modulated radiation therapy for cancers of the paranasal sinuses, nasal cavity, and lacrimal glands: Technique, early outcomes, and toxicity by Bradford S. Hoppe; Suzanne L. Wolden; Michael J. Zelefsky; James G. Mechalakos; Jatin P. Shah; Dennis H. Kraus; Nancy Lee is a Medicine article available to read on EtoBox.

What is Postoperative intensity‐modulated radiation therapy for cancers of the paranasal sinuses, nasal cavity, and lacrimal glands: Technique, early outcomes, and toxicity about?

## Abstract ## Background Our aim was to review Memorial Sloan‐Kettering Cancer Center's experience with postoperative intensity‐modulated radiotherapy (IMRT) for paranasal sinus, nasal cavity, and lacrimal gland cancer and report dosimetric measures, toxicity, and outcomes. ## Methods Between September 2000 and June 2006, 37 patients with paranasal sinus, nasal cavity, or lacrimal gland cancer underwent postoperative IMRT. Median values were as follows: prescription dose, 60 Gy (range, 50–70); PTV~D95~, 99% (range, 79–101%); optic nerve Dmax, 53 Gy (range, 2–54); optic chiasm Dmax, 51Gy (range, 2–55). Acute and late toxicities were scored by Radiation Therapy Oncology Group morbidity criteria. ## Results Median follow‐up was 28 months. Two‐year local progression–free and overall survivals were 75% and 80%. No early‐ or late‐grade 3/4 radiation‐induced ophthalmologic toxicity occurred. ## Conclusions Preliminary results show that adjuvant IMRT in these patients is feasible, allowed for excellent planning target volume (PTV) coverage, and minimized dose delivered to optic structures. Longer follow‐up is warranted to assess the extent of late effects and outcomes. © 2008 Wiley Period

Who reads Postoperative intensity‐modulated radiation therapy for cancers of the paranasal sinuses, nasal cavity, and lacrimal glands: Technique, early outcomes, and toxicity?

Author

Bradford S. Hoppe; Suzanne L. Wolden; Michael J. Zelefsky; James G. Mechalakos; Jatin P. Shah; Dennis H. Kraus; Nancy Lee

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1043-3074)

Published

2008

Language

EN

Field

Medicine (Health Sciences)