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Effect of Anticoagulant and Platelet Inhibition on the Risk of Bacteremia Among Patients with Acute Pyelonephritis: a Retrospective Cohort Study by Svava E. Steiner; Gustaf Edgren; Keira Melican; Agneta Richter-Dahlfors; Annelie Brauner is a Medicine article available to read on EtoBox.
What is Effect of Anticoagulant and Platelet Inhibition on the Risk of Bacteremia Among Patients with Acute Pyelonephritis: a Retrospective Cohort Study about?
## Background An increasing number of patients are being prescribed anticoagulants and platelet inhibitors (antithrombotic treatment). Basic research has suggested an association between antithrombotic treatment and bacteremia during kidney infection. Here, we investigated the association between antithrombotic treatment, bacteremia and acute kidney injury in patients with acute pyelonephritis. ## Methods A retrospective cohort study was conducted in a large university hospital in Sweden. Data were retrieved from electronic medical records for adult patients with acute pyelonephritis in 2016. The main outcome was bacteremia and secondary outcome acute kidney injury. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated through multiple logistic regression. Treatment with different groups of antithrombotic agents were compared to no antithrombotic treatment. ## Results 1814 patients with acute pyelonephritis were included, in whom bacteremia developed in 336 (18.5%). Low-molecular-weight heparin (LMWH) at prophylactic doses was associated with a lower risk of bacteremia, compared to no antithrombotic treatment (OR 0.5; 95% CI 0.3–0.7). Other antithrombotic treatments
Who reads Effect of Anticoagulant and Platelet Inhibition on the Risk of Bacteremia Among Patients with Acute Pyelonephritis: a Retrospective Cohort Study?
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- Author
- Svava E. Steiner; Gustaf Edgren; Keira Melican; Agneta Richter-Dahlfors; Annelie Brauner
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)