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Can I read Targeting Lactate Metabolism and Immune Interaction in Breast Tumor via Protease-triggered Delivery on EtoBox?
Targeting Lactate Metabolism and Immune Interaction in Breast Tumor via Protease-triggered Delivery by Pengfei Zhao; Shuang Wang; Jizong Jiang; Yanrong Gao; Yuewei Wang; Yuge Zhao; Jiaxin Zhang; Meng Zhang; Yongzhuo Huang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Targeting Lactate Metabolism and Immune Interaction in Breast Tumor via Protease-triggered Delivery about?
Lactate is abundant in cancer tissues due to active glycolysis (aka Warburg effect) and mediates crosstalk between tumor cells and the immune microenvironment (TIME) to promote the progression of breast cancer. Quercetin (QU) is a potent monocarboxylate transporters (MCT) inhibitor, which can reduce lactate production and secretion of tumor cells. Doxorubicin (DOX) can induce immunogenic cell death (ICD), which promotes tumor-specific immune activation. Thus, we propose a combination therapy of QU&DOX to inhibit lactate metabolism and stimulate anti-tumor immunity. To enhance tumor-targeting efficiency, we developed a legumain-activatable liposome system (KC26-Lipo) with modification of KC26 peptide for co-delivery of QU&DOX for modulation of tumor metabolism and TIME in breast cancer. The KC26 peptide is a legumain-responsive, hairpin-structured cell-penetrating peptide (polyarginine) derivative. Legumain is a protease overexpressed in breast tumors, allowing selective activation of the KC26-Lipo to subsequently facilitate intra-tumoral and intracellular penetration. The KC26-Lipo effectively inhibited 4T1 breast cancer tumor growth through chemotherapy and anti-tumor immunity. Be
Who reads Targeting Lactate Metabolism and Immune Interaction in Breast Tumor via Protease-triggered Delivery?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Pengfei Zhao; Shuang Wang; Jizong Jiang; Yanrong Gao; Yuewei Wang; Yuge Zhao; Jiaxin Zhang; Meng Zhang; Yongzhuo Huang
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)