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Can I read Review article: vascular effects of PPARs in the context of NASH on EtoBox?
Review article: vascular effects of PPARs in the context of NASH by Sergi Guixé‐Muntet; Louise Biquard; Gyongyi Szabo; Jean‐François Dufour; Frank Tacke; Sven Francque; Pierre‐Emmanuel Rautou; Jordi Gracia‐Sancho is a Medicine article available to read on EtoBox.
What is Review article: vascular effects of PPARs in the context of NASH about?
## Summary ## Background Peroxisome proliferator‐activated receptors (PPARs) are ligand‐activated transcription factors known to regulate glucose and fatty acid metabolism, inflammation, endothelial function and fibrosis. PPAR isoforms have been extensively studied in metabolic diseases, including type 2 diabetes and cardiovascular diseases. Recent data extend the key role of PPARs to liver diseases coursing with vascular dysfunction, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). ## Aim This review summarises and discusses the pathobiological role of PPARs in cardiovascular diseases with a special focus on their impact and therapeutic potential in NAFLD and NASH. ## Results and Conclusions PPARs may be attractive for the treatment of NASH due to their liver‐specific effects but also because of their efficacy in improving cardiovascular outcomes, which may later impact liver disease. Assessment of cardiovascular disease in the context of NASH trials is, therefore, of the utmost importance, both from a safety and efficacy perspective.
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- Author
- Sergi Guixé‐Muntet; Louise Biquard; Gyongyi Szabo; Jean‐François Dufour; Frank Tacke; Sven Francque; Pierre‐Emmanuel Rautou; Jordi Gracia‐Sancho
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)