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The Dependence of the Elastic Properties of Osteoporotic Cancellous Bone on Volume Fraction and Fabric by Jasper Homminga; Barbara R. Mccreadie; Harrie Weinans; Rik Huiskes is a Medicine article available to read on EtoBox.

What is The Dependence of the Elastic Properties of Osteoporotic Cancellous Bone on Volume Fraction and Fabric about?

Osteoporosis is a progressive systemic skeletal condition characterized by low bone mass and microarchitectural deterioration, with a consequent increase in susceptibility to fracture. Hence, osteoporosis would be best diagnosed by in vivo measurements of bone strength. As this is not clinically feasible, our goal is to estimate bone strength through the assessment of elastic properties, which are highly correlated to strength. Previously established relations between morphological parameters (volume fraction and fabric) and elastic constants could be applied to estimate cancellous bone stiffness in vivo. However, these relations were determined for normal cancellous bone. Cancellous bone from osteoporotic patients may require different relations. In this study we set out to answer two questions. First, can the elastic properties of osteoporotic cancellous bone be estimated from morphological parameters? Second, do the relations between morphological parameters and elastic constants, determined for normal bone, apply to osteoporotic bone as well? To answer these questions we used cancellous bone cubes from femoral heads of patients with (n 1⁄4 26) and without (n 1⁄4 32) hip fractur

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Author

Jasper Homminga; Barbara R. Mccreadie; Harrie Weinans; Rik Huiskes

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0021-9290)

Published

2003

Language

EN

Field

Medicine (Health Sciences)