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The study investigates the role of the neurotrophic factor MANF in regulating autophagy and lysosomal function in Caenorhabditis elegans, revealing its critical involvement in maintaining proteostasis and cellular stress responses. MANF-1 overexpression was found to extend lifespan, reduce protein aggregation, and improve neuronal survival, with its protective effects mediated by the transcription factor HLH-30/TFEB. The findings highlight MANF
- Author
- Amith Jupudy
- Language
- EN