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Reference distributions for complement proteins C3 and C4: A practical, simple and clinically relevant approach in a large cohort by Robert F. Ritchie; Glenn E. Palomaki; Louis M. Neveux; Olga Navolotskaia; Thomas B. Ledue; Wendy Y. Craig is a Medicine article available to read on EtoBox.

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## Abstract The two serum proteins of the complement cascade in the highest concentrations, C3 and C4, respond to various conditions in much the same manner as do other positive acute‐phase proteins. A major difference is that they are relatively sluggish in response to cytokine drive, requiring several days rather than hours to be detectably elevated by serial measurements. As with other acute‐phase proteins, there are many processes that up‐ or down‐regulate synthesis, including infection or inflammation, hepatic failure, and immune‐complex formation. Clinicians may find it difficult to distinguish among these processes, because they often occur simultaneously. The situation is further complicated by genetic polymorphism, with rare instances of markedly reduced synthesis and circulating levels, and consequent vulnerability to infection. C3 and C4 are measured for clinical purposes to help define certain rheumatic and immunologically mediated renal diseases. Interpreting the measured blood levels of these two components requires one to consider the intensity of the inflammatory drive, the timing of the suspected clinical process, the production of complement‐consuming immune compl

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Author

Robert F. Ritchie; Glenn E. Palomaki; Louis M. Neveux; Olga Navolotskaia; Thomas B. Ledue; Wendy Y. Craig

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-8013)

Published

2004

Language

EN

Field

Medicine (Health Sciences)