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Alveolar soft part sarcoma in children and adolescents: Clinical features and outcome of 11 patients by Pappo, Alberto S.; Parham, David M.; Cain, Alvida; Luo, Xiaolong; Bowman, Laura C.; Furman, Wayne L.; Rao, Bhaskar N.; Pratt, Charles B. is a Medicine article available to read on EtoBox.
What is Alveolar soft part sarcoma in children and adolescents: Clinical features and outcome of 11 patients about?
The clinical features and response to therapy of pediatric alveolar soft part sarcoma, a rare soft tissue sarcoma of uncertain histogenesis, have not been previously described in detail in the literature. We retrospectively reviewed the clinical characteristics of all patients with alveolar soft part sarcoma who were seen at our institution over a 32-year period. We found 11 patients with the diagnosis of alveolar soft part sarcoma. Their ages ranged from 2.8-16 years (median 9.8). Staging was determined using the Intergroup Rhabdomyosarcoma Study clinical grouping system and the UlCC TNM system. Accordingly, there were six patients with grossly resected tumors (clinical groups I and II) and five with unresected or meta-static disease (clinical groups Ill and IV). Children with resected disease were more likely to have smaller noninvasive tumors. The main feature predictive of survival was tumor resectability, since chemotherapy in various combinations failed to produce significant tumor responses. Nine patients are disease-free with a median follow-up of 11.9 years. Surgical resection remains the mainstay of therapy for pediatric alveolar soft part sarcoma. Since active chemothera
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- Author
- Pappo, Alberto S.; Parham, David M.; Cain, Alvida; Luo, Xiaolong; Bowman, Laura C.; Furman, Wayne L.; Rao, Bhaskar N.; Pratt, Charles B.
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0098-1532)
- Published
- 1996
- Language
- EN
- Field
- Medicine (Health Sciences)