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Can I read Acetylcholinesterase Inhibition Protects Against Trastuzumab-induced Cardiotoxicity Through Reducing Multiple Programmed Cell Death Pathways on EtoBox?
Acetylcholinesterase Inhibition Protects Against Trastuzumab-induced Cardiotoxicity Through Reducing Multiple Programmed Cell Death Pathways by Thawatchai Khuanjing; Chayodom Maneechote; Benjamin Ongnok; Nanthip Prathumsap; Apiwan Arinno; Titikorn Chunchai; Busarin Arunsak; Siriporn C. Chattipakorn; Nipon Chattipakorn is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Acetylcholinesterase Inhibition Protects Against Trastuzumab-induced Cardiotoxicity Through Reducing Multiple Programmed Cell Death Pathways about?
## Background Trastuzumab (Trz)-induced cardiotoxicity (TIC) is one of the most common adverse effects of targeted anticancer agents. Although oxidative stress, inflammation, mitochondrial dysfunction, apoptosis, and ferroptosis have been identified as potential mechanisms underlying TIC, the roles of pyroptosis and necroptosis under TIC have never been investigated. It has been shown that inhibition of acetylcholinesterase function by using donepezil exerts protective effects in various heart diseases. However, it remains unknown whether donepezil exerts anti-cardiotoxic effects in rats with TIC. We hypothesized that donepezil reduces mitochondrial dysfunction, inflammation, oxidative stress, and cardiomyocyte death, leading to improved left ventricular (LV) function in rats with TIC. ## Methods Male Wistar rats were randomly assigned to be Control or Trz groups (Trz 4 mg/kg/day, 7 days, I.P.). Rats in Trz groups were assigned to be co-treated with either drinking water (Trz group) or donepezil 5 mg/kg/day (Trz + DPZ group) via oral gavage for 7 days. Cardiac function, heart rate variability (HRV), and biochemical parameters were evaluated. ## Results Trz-treated rats had impaired
Who reads Acetylcholinesterase Inhibition Protects Against Trastuzumab-induced Cardiotoxicity Through Reducing Multiple Programmed Cell Death Pathways?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Thawatchai Khuanjing; Chayodom Maneechote; Benjamin Ongnok; Nanthip Prathumsap; Apiwan Arinno; Titikorn Chunchai; Busarin Arunsak; Siriporn C. Chattipakorn; Nipon Chattipakorn
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)