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Correlates of preclinical cardiovascular disease in Indigenous and Non-Indigenous Australians: a case control study by Brian A Haluska; Lionel Chan; Leanne Jeffriess; A Andrew Shaw; Joanne Shaw; Thomas H Marwick is a Medicine article available to read on EtoBox.

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## Background The high frequency of premature death from cardiovascular disease in indigenous Australians is often attributed to the high prevalence of risk factors, especially type II diabetes mellitus (DM). We evaluated the relationship of ethnicity to atherosclerotic burden, as evidenced by carotid intima-media thickness (IMT), independent of risk factor status. ## Methods We studied 227 subjects (147 men; 50 ± 13 y): 119 indigenous subjects with (IDM, n = 54), and without DM (InDM, n = 65), 108 Caucasian subjects with (CDM, n = 52), and without DM (CnDM, n = 56). IMT was measured according to standard methods and compared with clinical data and cardiovascular risk factors. ## Results In subjects both with and without DM, IMT was significantly greater in indigenous subjects. There were no significant differences in gender, body mass index (BMI), systolic blood pressure (SBP), or diastolic blood pressure (DBP) between any of the groups, and subjects with DM showed no difference in plasma HbA1c. Cardiovascular risk factors were significantly more prevalent in indigenous subjects. Nonetheless, ethnicity (β = -0.34; p < 0.0001), age (β = 0.48; p < 0.0001), and smoking (β = 0.13; p <

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Author

Brian A Haluska; Lionel Chan; Leanne Jeffriess; A Andrew Shaw; Joanne Shaw; Thomas H Marwick

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London UK: BioMed Central, 2003-; Springer Science and Business Media LLC (ISSN 1476-7120)

Published

2008

Language

EN

Field

Medicine (Health Sciences)