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Efficacy and Safety of High-dose Budesonide/formoterol in Patients with Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplant by Kyung Hoon Kim; Jongmin Lee; Hee-Je Kim; Seok Lee; Yoo-Jin Kim; Jong Hyuk Lee; Chin Kook Rhee is a Medicine article available to read on EtoBox.
What is Efficacy and Safety of High-dose Budesonide/formoterol in Patients with Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplant about?
## Background Bronchiolitis obliterans syndrome (BOS) is a rare, progressive and irreversible airway disease associated with significant mortality after allogeneic hematopoietic stem-cell transplantation (HSCT). In this study, we investigated the therapeutic effect of high-dose budesonide/formoterol (320/9 μg bid) in patients with BOS after HSCT already using low-dose budesonide/formoterol (160/4.5 μg bid). ## Methods After a retrospective chart review, patients who were initially treated with budesonide/formoterol 160/4.5 μg bid and increased their dose to 320/9 μg bid between March 2009 and February 2019 were enrolled. Pulmonary function test (PFT) and COPD assessment test (CAT) were performed before and after changing the drug dose. Efficacy was assessed within 3 months after increasing the drug dose; the primary variable was changes in forced expiratory volume in 1 second (FEV1) and CAT score. Safety was assessed as the incidence of pneumonia within 3 months after increasing the drug dose. ## Results Seventy-seven patients were treated with budesonide 160 μg plus formoterol 4.5 μg twice a day for more than 3 months and the dose was increased to budesonide 320 μg plus 9.0 μg twi
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- Author
- Kyung Hoon Kim; Jongmin Lee; Hee-Je Kim; Seok Lee; Yoo-Jin Kim; Jong Hyuk Lee; Chin Kook Rhee
- Publisher
- AME Publishing Company; Hong Kong: Pioneer Bioscience Publishing Company (ISSN 2072-1439)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)