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Altered gene activity correlated with long-term memory formation of conditioned taste aversion in Lymnaea by Sachiyo Azami; Akiko Wagatsuma; Hisayo Sadamoto; Dai Hatakeyama; Takeshi Usami; Manabu Fujie; Ryo Koyanagi; Kaoru Azumi; Yutaka Fujito; Ken Lukowiak; Etsuro Ito is a Neuroscience article available to read on EtoBox.

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## Abstract The pond snail __Lymnaea stagnalis__ is capable of learning conditioned taste aversion (CTA) and then consolidating that learning into long‐term memory (LTM) that persists for at least 1 month. LTM requires de novo protein synthesis and altered gene activity. Changes in gene activity in __Lymnaea__ that are correlated with, much less causative, memory formation have not yet been identified. As a first step toward rectifying this situation, we constructed a cDNA microarray with mRNAs extracted from the central nervous system (CNS) of __Lymnaea__. We then, using this microarray assay, identified genes whose activity either increased or decreased following CTA memory consolidation. We also identified genes whose expression levels were altered after inhibition of the cyclic AMP response element‐binding protein (CREB) that is hypothesized to be a key transcription factor for CTA memory. We found that the molluscan insulin‐related peptide II (MIP II) was up‐regulated during CTA‐LTM, whereas the gene encoding pedal peptide preprohormone (Pep) was down‐regulated by CREB2 RNA interference. We next examined mRNAs of MIP II and Pep using real‐time RT‐PCR with SYBR Green. The MIP I

Who reads Altered gene activity correlated with long-term memory formation of conditioned taste aversion in Lymnaea?

Author

Sachiyo Azami; Akiko Wagatsuma; Hisayo Sadamoto; Dai Hatakeyama; Takeshi Usami; Manabu Fujie; Ryo Koyanagi; Kaoru Azumi; Yutaka Fujito; Ken Lukowiak; Etsuro Ito

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)

Published

2006

Language

EN

Field

Neuroscience (Life Sciences)