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Metabolic Hallmarks of Metastasis Formation by Ilaria Elia; Ginevra Doglioni; Sarah-Maria Fendt is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Metabolic Hallmarks of Metastasis Formation about?

Metastasis to distant organs is a predictor of poor prognosis. Therefore, it is of paramount importance to understand the mechanisms that impinge on the different steps of the metastatic cascade. Recent work has revealed that particular metabolic pathways are rewired in cancer cells to support their transition through the metastatic cascade, resulting in the formation of secondary tumors in distant organs. Indeed, metabolic rewiring induces signaling pathways during initial cancer invasion, circulating cancer cells depend on enhanced antioxidant defenses, and cancer cells colonizing a distant organ require increased ATP production. Moreover, the local environment of the metastatic niche dictates the metabolic pathways secondary tumors rely on. Here we describe mechanisms of metabolic rewiring associated with distinct steps of metastasis formation.

Who reads Metabolic Hallmarks of Metastasis Formation?

Author

Ilaria Elia; Ginevra Doglioni; Sarah-Maria Fendt

Published

2018

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)