Opening book details…
Can I read Do We Need to Do Fluorescence in Situ Hybridization Analysis in Myelodysplastic Syndromes as Often as We Do? on EtoBox?
Do We Need to Do Fluorescence in Situ Hybridization Analysis in Myelodysplastic Syndromes as Often as We Do? by Dolors Costa; Sandra Valera; Ana Carrió; Amparo Arias; Concha Muñoz; María Rozman; Mohamed Belkaid; Rita Coutinho; Benet Nomdedeu; Elias Campo is a Medicine article available to read on EtoBox.
What is Do We Need to Do Fluorescence in Situ Hybridization Analysis in Myelodysplastic Syndromes as Often as We Do? about?
Although conventional cytogenetics is considered the gold standard to detect chromosomal abnormalities in myelodysplastic syndromes (MDS), fluorescence in situ hybridization (FISH) is being increasingly used additionally. However, the real contribution of FISH analysis in the cytogenetic diagnosis of MDS has not been well defined. The aim of this study was to evaluate whether FISH studies are able to reveal chromosomal abnormalities in MDS patients undetected by conventional cytogenetics. One hundred seventy-four FISH studies were performed on bone marrow samples of 60 patients with MDS. The number of FISH studies in each patient was variable (1-5). FISH studies confirmed the G-banding cytogenetic findings in 99.4% (153/154) of samples and detected cytogenetic abnormalities in 25% (5/20) of cases in which the conventional cytognetic study failed. These results indicate that FISH studies provide relevant information in MSD in which the conventional cytogenetic analysis was unsuccessful but add little value to a normal katyotype in conventional cytogenetic analysis.
Who reads Do We Need to Do Fluorescence in Situ Hybridization Analysis in Myelodysplastic Syndromes as Often as We Do??
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Dolors Costa; Sandra Valera; Ana Carrió; Amparo Arias; Concha Muñoz; María Rozman; Mohamed Belkaid; Rita Coutinho; Benet Nomdedeu; Elias Campo
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0145-2126)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)