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A water soluble extract from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin by Thomas Mammone; Christina Åkesson; David Gan; Vincent Giampapa; Ronald W. Pero is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Cat's Claw (__Uncaria tomentosa__) water extracts, essentially free of oxindole alkaloids, have been shown to possess a broad spectrum of biological activity including DNA repair enhancement and antiinflammatory properties. These two biological mechanisms are key molecular targets to develop treatments that protect skin exposed to ultraviolet light from the sun. Because C‐Med‐100, a Cat's Claw water extract, is the only documented natural source of components that can up‐regulate simultaneously both DNA repair and antiinflammation, its ability to modulate DNA repair in human skin organ cultures was undertaken. For this purpose skin cultures were treated with or without 5 mg/mL C‐Med‐100, irradiated with 0–100 mJ/cm^2^ UVB, and microscopically analysed for necrosis as well as the level of pyrimidine dimers using immunofluorescent TT‐dimer antibody staining. The data clearly demonstrated that co‐incubation with C‐Med‐100 reduced skin cell death from UV exposure, and this protection was accounted for by a concomitant increase in DNA repair. Based on these results, it was concluded that C‐Med‐100 was a natural plant extract worthy of further consideration as a sunscreen pro

Who reads A water soluble extract from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin?

Author

Thomas Mammone; Christina Åkesson; David Gan; Vincent Giampapa; Ronald W. Pero

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)

Published

2006

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)