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Can I read Distinct Immunopathology in the Early Stages Between Different Antiresorptives-related Osteonecrosis of the Jaw-like Lesions in Mice on EtoBox?
Distinct Immunopathology in the Early Stages Between Different Antiresorptives-related Osteonecrosis of the Jaw-like Lesions in Mice by Hayano, Hiroki; Kuroshima, Shinichiro; Sasaki, Muneteru; Tamaki, Saki; Inoue, Maaya; Ishisaki, Akira; Sawase, Takashi is a Medicine article available to read on EtoBox.
What is Distinct Immunopathology in the Early Stages Between Different Antiresorptives-related Osteonecrosis of the Jaw-like Lesions in Mice about?
There is limited information about denosumab-related osteonecrosis of the jaw (DRONJ), unlike bisphosphonate-related ONJ (BRONJ). The mode of action is clearly different between denosumab and bisphosphonates. DRONJ occurs mainly following tooth extraction in cancer patients treated with the combination of denosumab and other drugs including chemotherapy. However, DRONJ animal models similar to these clinical situations have not been developed. The aims of this study were to 1) create a new model of high-prevalence chemotherapy/anti-RANKL antibody-related ONJ-like lesions to mimic patients receiving a denosumab/chemotherapy combination; and 2) compare the histopathological and immunopathological findings in the early stages of BRONJ-like and anti-RANKL antibody-related ONJ-like lesions. Cyclophosphamide (CY) and anti-mouse RANKL monoclonal antibody (mAb) or zoledronate combination therapy (CY/mAb and CY/ZA, respectively) was performed to create ONJ-like lesions in female C57BL/6J mice. Both maxillary first molars were extracted at 3 weeks after drug administration. The animals were euthanized at either 2 or 4 weeks after tooth extraction. Increased necrotic bone and empty lacunae wi
Who reads Distinct Immunopathology in the Early Stages Between Different Antiresorptives-related Osteonecrosis of the Jaw-like Lesions in Mice?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Hayano, Hiroki; Kuroshima, Shinichiro; Sasaki, Muneteru; Tamaki, Saki; Inoue, Maaya; Ishisaki, Akira; Sawase, Takashi
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 8756-3282)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)