Opening book details…
Can I read An Azido-functionalized Isocarbacyclin Analogue Acting as an Efficient Photoaffinity Probe for a Prostacyclin Receptor on EtoBox?
An Azido-functionalized Isocarbacyclin Analogue Acting as an Efficient Photoaffinity Probe for a Prostacyclin Receptor by Masaaki Suzuki; Hiroshi Koyano; Ryoji Noyori; Hitoshi Hashimoto; Manabu Negishi; Atsushi Ichikawa; Seiji Ito is a Chemistry article available to read on EtoBox.
What is An Azido-functionalized Isocarbacyclin Analogue Acting as an Efficient Photoaffinity Probe for a Prostacyclin Receptor about?
## A stable prostacyqlin analogue, (15s)~18~ having an azidophenyl group as a photoaffinity labeling functionality has been synthesized. This compound has a sujkiently high afinity to the prostacyclin receptor protein in mastocywma P-815 cells, exhibiting an ICso value of 3 nM for the replacement of iloprost bound to the receptor protein. A photoafinit>t probe compound, [3H]-(US)-l8c, is obtainable by reduction of the ketone Ibc with 13HJNaBH.g -CeC13 followed by alkaline hydrolysis of the methyl ester.
Who reads An Azido-functionalized Isocarbacyclin Analogue Acting as an Efficient Photoaffinity Probe for a Prostacyclin Receptor?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Masaaki Suzuki; Hiroshi Koyano; Ryoji Noyori; Hitoshi Hashimoto; Manabu Negishi; Atsushi Ichikawa; Seiji Ito
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4020)
- Published
- 1992
- Language
- EN
- Field
- Chemistry (Physical Sciences)