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Association of Frailty, Age, and Biological Sex With Severe Acute Respiratory Syndrome Coronavirus 2 Messenger RNA Vaccine–Induced Immunity in Older Adults by Janna R Shapiro; Ioannis Sitaras; Han Sol Park; Tihitina Y Aytenfisu; Christopher Caputo; Maggie Li; John Lee; Trevor S Johnston; Huifen Li; Camille Wouters; Pricila Hauk; Henning Jacobsen; Yukang Li; Engle Abrams; Steve Yoon; Andrew J Kocot; Tianrui Yang; Yushu Huang; Steven M Cramer; Michael J Betenbaugh; Amanda K Debes; Rosemary Morgan; Aaron M Milstone; Andrew H Karaba; Andrew Pekosz; Sean X Leng; Sabra L Klein is a Medicine article available to read on EtoBox.

What is Association of Frailty, Age, and Biological Sex With Severe Acute Respiratory Syndrome Coronavirus 2 Messenger RNA Vaccine–Induced Immunity in Older Adults about?

## Abstract ## Background Male sex and old age are risk factors for severe coronavirus disease 2019, but the intersection of sex and aging on antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines has not been characterized. ## Methods Plasma samples were collected from older adults (aged 75–98 years) before and after 3 doses of SARS-CoV-2 mRNA vaccination, and from younger adults (aged 18–74 years) post-dose 2, for comparison. Antibody binding to SARS-CoV-2 antigens (spike protein [S], S receptor-binding domain, and nucleocapsid), functional activity against S, and live-virus neutralization were measured against the vaccine virus and the Alpha, Delta, and Omicron variants of concern (VOCs). ## Results Vaccination induced greater antibody titers in older females than in older males, with both age and frailty associated with reduced antibody responses in males but not females. Responses declined significantly in the 6 months after the second dose. The third dose restored functional antibody responses and eliminated disparities caused by sex, age, and frailty in older adults. Responses to the VOCs, particularly the Omicron variant, were significan

Who reads Association of Frailty, Age, and Biological Sex With Severe Acute Respiratory Syndrome Coronavirus 2 Messenger RNA Vaccine–Induced Immunity in Older Adults?

Author

Janna R Shapiro; Ioannis Sitaras; Han Sol Park; Tihitina Y Aytenfisu; Christopher Caputo; Maggie Li; John Lee; Trevor S Johnston; Huifen Li; Camille Wouters; Pricila Hauk; Henning Jacobsen; Yukang Li; Engle Abrams; Steve Yoon; Andrew J Kocot; Tianrui Yang; Yushu Huang; Steven M Cramer; Michael J Betenbaugh; Amanda K Debes; Rosemary Morgan; Aaron M Milstone; Andrew H Karaba; Andrew Pekosz; Sean X Leng; Sabra L Klein

Publisher

Oxford University Press (OUP)

Published

2022

Language

EN

Field

Medicine (Health Sciences)