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A Randomized Trial of Delayed Extubation for the Reduction of Reintubation in Extremely Preterm Infants by Claude Danan; Xavier Durrmeyer; Laurent Brochard; Fabrice Decobert; Mohamed Benani; Gilles Dassieu is a Medicine article available to read on EtoBox.
What is A Randomized Trial of Delayed Extubation for the Reduction of Reintubation in Extremely Preterm Infants about?
## Abstract ## Objective To compare immediate extubation versus delayed extubation after 36 hr in extremely low‐birth weight infants receiving gentle mechanical ventilation and perinatal lung protective interventions. Our hypothesis was that a delayed extubation in this setting would decrease the rate of reintubation. ## Study design/Methodology A prospective, unmasked, randomized, controlled trial to compare immediate extubation and delayed extubation after 36 hr. Optimized ventilation in both groups included continuous tracheal gas insufflation (CTGI), prophylactic surfactant administration, low oxygen saturation target and moderate permissive hypercapnia. Successful extubation for at least 7 days was the primary criterion and ventilatory support requirements until 36 weeks gestational age the main secondary criteria. ## Patient selection Eighty‐six infants under 28 weeks gestational age in a single neonatal intensive tertiary care unit. ## Results Delayed extubation (1.9 ± 0.8 days vs. 0.5 ± 0.7 days) did not improve the rate of successful extubation but had no long‐term adverse effects. CTGI and the lung protective strategy we describe resulted in a very gentle ventilation. The
Who reads A Randomized Trial of Delayed Extubation for the Reduction of Reintubation in Extremely Preterm Infants?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Claude Danan; Xavier Durrmeyer; Laurent Brochard; Fabrice Decobert; Mohamed Benani; Gilles Dassieu
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 8755-6863)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)