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Do Brain Regions Involved in Threat Processing Mediate the Association Between Developmental Trauma and Psychosis by P.G.Y. Jung; A. Mason; K. Merritt; E. McCrory; J.P. Roiser; D.K. Jones; S. Zammit; A.S. David; M.A.P. Bloomfield is a Medicine article available to read on EtoBox.
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system is known to be the key regulator of energy homeostasis, it is mediated through a family of five related G protein-coupled melanocortin receptors, melanocortin 1 receptor through melanocortin 5 receptor, whereas only melanocortin 3 receptor (MC3R) and melanocortin 4 receptor are expressed in the brain. Mice lacking MC3R have been shown to have abnormal responses to fasting, shown by inappropriate refeeding behavior and altered corticosterone levels. However, where these MC3R neurons are acting to mediate effects of nutritional stresses such as fasting is unknown. In addition, recent work shows a role for MC3R in social behaviors as well. Therefore, in this study, we aimed to decipher the role of melanocortin-3-receptor in feeding behavior under various conditions. We also aim to explore the specific projections of MC3R into different brain regions. We studied the role of MC3R modulation in two different stress paradigms (nutritional and non-nutritional) using the DREADD mouse model. We used MC3R-Cre; ROSA26-LSL-hm3DGq and MC3R-Cre; ROSA26-LSL-hm4DGi mice. Wildtype C57BL/6N mice were also used for control. The mice receive either CNO or Saline on the day of experiment. For the
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- Author
- P.G.Y. Jung; A. Mason; K. Merritt; E. McCrory; J.P. Roiser; D.K. Jones; S. Zammit; A.S. David; M.A.P. Bloomfield
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)