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Systemic Bioavailability and Pharmacokinetics of Methylprednisolone in Patients with Rheumatoid Arthritis Following ‘High-dose’ Pulse Administration by P. K. Narang; R. Wilder; D. C. Chatterji; R. L. Yeager; J. F. Gallelli is a Medicine article available to read on EtoBox.

What is Systemic Bioavailability and Pharmacokinetics of Methylprednisolone in Patients with Rheumatoid Arthritis Following ‘High-dose’ Pulse Administration about?

The absolute and relative bioavailability of two methylprednisolone formulations (capsules and suspension) was determined along with its pharmacokinetics in -four arthritic female patients, following an unconventional high-dose pulse of 1 g. Plasma concentrations of the drug were measured by a sensitive and specific high-performance liquid chromatographic (HPLC) procedure. The disposition of methylprednisolone from plasma following intravenous (i.v.) infusion of its succinate ester appeared monoexponential with a mean half-life of 2.4 h and an apparent volume of distribution (V,,) of 50 1 (0.87 I/kg). The total body clearance (CI) averaged 15.12 I/h. Absolute bioavailability was assessed by comparing the areas under the plasma concentration time curves (normalized to dose) following oral administration of capsule or suspension with those of intravenous administration. N o significant difference (p > 0.2) was observed when systemic availability (,L expressed in per cent) following administration of drug in capsule ( f = 49.35 per cent) was compared with that obtained following the administration of drug in a suspension (.f = 58.26 per cent). The difference in the observed and predic

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Author

P. K. Narang; R. Wilder; D. C. Chatterji; R. L. Yeager; J. F. Gallelli

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0142-2782)

Published

1983

Language

EN

Field

Medicine (Health Sciences)