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Long-term vs. Short-term Androgen Deprivation Therapy in Patients Treated with External Beam Radiotherapy for High-risk Prostate Cancer in the PSA Era by A.D. Vassil; C. Reddy; C. Robinson; J. Ciezki is a Medicine article available to read on EtoBox.

What is Long-term vs. Short-term Androgen Deprivation Therapy in Patients Treated with External Beam Radiotherapy for High-risk Prostate Cancer in the PSA Era about?

Purpose/Objective(s): To assess the effect of duration of androgen deprivation (AD) therapy on distant metastases free survival (DMFS) and prostate cancer specific mortality (PCSM) in patients with high-risk prostate cancer (HRPC) treated with high dose radiation therapy in the PSA era. Materials/Methods: Patients treated using external beam radiotherapy (EBRT) with $78Gy biologic equivalent dose for HRPC in 1996-2007 were studied. HRPC was defined as pretreatment PSA (iPSA) .20 ng/mL, biopsy Gleason score (bGS) 8-10, clinical stage T3, having two intermediate risk factors: clinical stage T2b or T2c, bGS 7, or iPSA 10-20 ng/mL. All patients had at least 2 post-treatment PSA tests. Multivariate analysis (MVA) with Cox proportional hazards regression was used to examine variables which may affect biochemical recurrence free survival (bRFS), DMFS and PCSM: Charlson score; age; race; BMI; iPSA; bGS; clinical stage; use and duration of AD (1-6 months vs. .6 months; and as a continuous variable). bRFS rates were calculated using the nadir+2 definition of biochemical failure (bF). Distant failure included any radiographic recurrence of cancer outside of the prostate. Results: A total of 5

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Author

A.D. Vassil; C. Reddy; C. Robinson; J. Ciezki

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2010

Language

EN

Field

Medicine (Health Sciences)