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How kinetically accessible is an RNA target for hybridization with an antisense oligo? A lesson from an RNA target which is as small as a 20mer by Nitin Puri; Jyoti Chattopadhyaya is a Chemistry article available to read on EtoBox.
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A 20met RNA (1), ~ as a duplex with two A.A mismatch baselmirs a~l fore" tandem CoU wobble I~airs, was targeted at the first A.A internal loop by nonmneaSc 5'-Polyarene DNA-cunjugates. For comparison, its DNA counterpart (10), which was found to form a laa~in with one A.A mismatch and a four nucleofide loop, was targeted at the single stranded loop starting from the AoA in.real loop. The sec~td~ structure of the duplex RNA (1) could not be ~ by the DNAconjugates while the lmirpln DNA (10) was fomKI to hybridize successfully, tl~a-eby slaowing the intrinsic ability ofRNA (coml~red to DNA oountea'pcrt) to fold into a terlimy sttuetme that is kinetically dift'~ult to aece~ for helerOdUl~CX folmafio, by an antiseme ODN.
Who reads How kinetically accessible is an RNA target for hybridization with an antisense oligo? A lesson from an RNA target which is as small as a 20mer?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Nitin Puri; Jyoti Chattopadhyaya
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4020)
- Published
- 1999
- Language
- EN
- Field
- Chemistry (Physical Sciences)