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Miniaturized hollow fiber assisted liquid-phase microextraction with in situ derivatization and gas chromatography–mass spectrometry for analysis of bisphenol A in human urine sample by Migaku Kawaguchi; Rie Ito; Noriya Okanouchi; Koichi Saito; Hiroyuki Nakazawa is a Chemistry article available to read on EtoBox.

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A new method that involves miniaturized hollow fiber assisted liquid-phase microextraction (HF-LPME) with in situ derivatization and gas chromatography-mass spectrometry (GC-MS) is described for the determination of trace amounts of bisphenol A (BPA) in human urine samples. The detection limit and the quantification limit of BPA in human urine sample are 0.02 and 0.1 ng ml(-1) (ppb), respectively. The calibration curve for BPA is linear with a correlation coefficient of >0.999 in the range of 0.1-50 ng ml(-1). The average recoveries of BPA in human urine samples spiked with 1 and 5 ng ml(-1) BPA are 101.0 (R.S.D.: 6.7%) and 98.8 (R.S.D.: 1.8%), respectively, with correction using the added surrogate standard, bisphenol A-(13)C12. This simple, accurate, sensitive and selective analytical method can be applicable to the determination of trace amounts of BPA in human urine samples.

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Author

Migaku Kawaguchi; Rie Ito; Noriya Okanouchi; Koichi Saito; Hiroyuki Nakazawa

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-376X)

Published

2008

Language

EN

Field

Chemistry (Physical Sciences)