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Mitochondrial replication origin stability and propensity of adjacent tRNA genes to form putative replication origins increase developmental stability in Lizards by Hervé Seligmann; Neeraja M. Krishnan is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Mitochondrial replication origin stability and propensity of adjacent tRNA genes to form putative replication origins increase developmental stability in Lizards about?
Secondary structure stability of mitochondrial origins of light-strand replication (OL) presumably reduces delayed formation of light-strand initiating replication forks on the heavy strand. Delayed replication initiation prolongs single strandedness of the heavy strand. More mutations accumulate during the prolonged time spent single stranded. Presumably, delayed replication initiation and excess mutations affect mitochondrial biochemical processes and ultimately morphological outcomes of development at the whole-organism level. This predicts that developmental stability increases with OL secondary structure stability and with formation of OL-like structures by the five tRNA genes flanking recognized OLs. Stable OLs and high percentages of OL-resembling secondary structures of adjacent tRNA genes (predicted by Mfold) correlate positively with developmental stability in three lizard families (Anguidae, Amphisbaenidae, and Polychrotidae). Accounting for effects of the regular OL, Sfold-predicted OL-like propensity of the entire tRNA gene cluster (not of individual genes) correlates with increased developmental stability in Anguidae, also across the entire free-energy range of Boltzm
Who reads Mitochondrial replication origin stability and propensity of adjacent tRNA genes to form putative replication origins increase developmental stability in Lizards?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Hervé Seligmann; Neeraja M. Krishnan
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1552-5007)
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)