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Five-years Surveillance of Invasive Aspergillosis in a University Hospital by Karolin Graf; Somayeh Mohammad Khani; Ella Ott; Frauke Mattner; Petra Gastmeier; Dorith Sohr; Stefan Ziesing; Iris F Chaberny is a Medicine article available to read on EtoBox.
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## Background As the most common invasive fungal infection, invasive aspergillosis (IA) remains a serious complication in immunocompromised patients, leading to increased mortality. Antifungal therapy is expensive and may result in severe adverse effects. The aim of this study was to determine the incidence of invasive aspergillosis (IA) cases in a tertiary care university hospital using a standardized surveillance method. ## Methods All inpatients at our facility were screened for presence of the following parameters: positive microbiological culture, pathologist's diagnosis and antifungal treatment as reported by the hospital pharmacy. Patients fulfilling one or more of these indicators were further reviewed and, if appropriate, classified according to international consensus criteria (EORTC). ## Results 704 patients were positive for at least one of the indicators mentioned above. Applying the EORTC criteria, 214 IA cases were detected, of which 56 were proven, 25 probable and 133 possible. 44 of the 81 (54%) proven and probable cases were considered health-care associated. 37 of the proven/probable IA cases had received solid organ transplantation, an additional 8 had undergone
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- Author
- Karolin Graf; Somayeh Mohammad Khani; Ella Ott; Frauke Mattner; Petra Gastmeier; Dorith Sohr; Stefan Ziesing; Iris F Chaberny
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2334)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)