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Biological activities of extracts and compounds from Thai Kae-Lae ( Maclura cochinchinensis (Lour.) Corner) by Lapamas Rueankham; Pawaret Panyajai; Aroonchai Saiai; Methee Rungrojsakul; Singkome Tima; Sawitree Chiampanichayakul; Kankanit Yeerong; Suvimol Somwongin; Wantida Chaiyana; Pornngarm Dejkriengkraikul; Siriporn Okonogi; Trinnakorn Katekunlaphan; Songyot Anuchapreeda is a Medicine article available to read on EtoBox.
What is Biological activities of extracts and compounds from Thai Kae-Lae ( Maclura cochinchinensis (Lour.) Corner) about?
## Background and aims The purpose of this study was to investigate the biological properties of Kae-Lae (__Maclura cochinchinensis__ (Lour.) Corner), a traditional medicinal plant used in Ayurvedic recipes in Thailand. To achieve this objective, heartwood samples were collected from 12 sources across Thailand. Fractional extracts (__n__-hexane, ethyl acetate, and ethanol) and the dominant compounds (morin, resveratrol, and quercetin) were examined for their abilities on cytotoxicity, antioxidant, anti-inflammation, and antileukaemic activity (Wilms’ tumour 1 protein was used as a well-known biomarker for leukaemic cell proliferation). ## Methods The study used MTT to assess cytotoxicity in leukaemic cells (K562, EoL-1, and KG-1a). Antioxidant activities were evaluated using ABTS, DPPH, and FRAP assays. The anti-inflammatory activity was investigated by detecting IL-2, TNF-α, and NO using appropriate detection kits. Wilms’ tumour 1 protein expression was measured by Western blotting to determine the anti-leukaemic activity. The inhibition of cell migration was also analyzed to confirm anticancer progression. ## Results Among the tested extract fraction, ethyl acetate No. 001 displa
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- Author
- Lapamas Rueankham; Pawaret Panyajai; Aroonchai Saiai; Methee Rungrojsakul; Singkome Tima; Sawitree Chiampanichayakul; Kankanit Yeerong; Suvimol Somwongin; Wantida Chaiyana; Pornngarm Dejkriengkraikul; Siriporn Okonogi; Trinnakorn Katekunlaphan; Songyot Anuchapreeda
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)