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Gut microbiota and ionizing radiation-induced damage: Is there a link? by Yueqiu Yu; Xiang Lin; Feiyang Feng; Yuanyun Wei; Shuang Wei; Yaqi Gong; Caimao Guo; Qingyu Wang; Peimeng Shuai; Tiantian Wang; Hui Qin; Guoqing Li; Lan Yi is a Environmental Science article available to read on EtoBox.

What is Gut microbiota and ionizing radiation-induced damage: Is there a link? about?

According to observational findings, ionizing radiation (IR) triggers dysbiosis of the intestinal microbiota, affecting the structural composition, function, and species of the gut microbiome and its metabolites. These modifications can further exacerbate IR-induced damage and amplify proinflammatory immune responses. Conversely, commensal bacteria and favorable metabolites can remodel the IR-disturbed gut microbial structure, promote a balance between anti-inflammatory and proinflammatory mechanisms in the body, and mitigate IR toxicity. The discovery of effective and safe remedies to prevent and treat radiation-induced injuries is vitally needed because of the proliferation of radiation toxicity threats produced by recent radiological public health disasters and increasing medical exposures. This review examines how the gut microbiota and its metabolites are linked to the processes of IR-induced harm. We highlight protective measures based on interventions with gut microbes to optimize the distress caused by IR damage to human health. We offer prospects for research in emerging and promising areas targeting the prevention and treatment of IR-induced damage.

Who reads Gut microbiota and ionizing radiation-induced damage: Is there a link??

Author

Yueqiu Yu; Xiang Lin; Feiyang Feng; Yuanyun Wei; Shuang Wei; Yaqi Gong; Caimao Guo; Qingyu Wang; Peimeng Shuai; Tiantian Wang; Hui Qin; Guoqing Li; Lan Yi

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Environmental Science (Physical Sciences)