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−93G→A polymorphism of hMLH1 and risk of primary lung cancer by Sun Ha Park; Ga Young Lee; Hyo‐Sung Jeon; Su Jeong Lee; Kyung Mee Kim; Sang Soo Jang; Chang Ho Kim; Won Kee Lee; Sin Kam; Rang Woon Park; In‐San Kim; Tae Hoon Jung; Jae Yong Park is a Medicine article available to read on EtoBox.
What is −93G→A polymorphism of hMLH1 and risk of primary lung cancer about?
## Abstract Polymorphisms in DNA repair genes may be associated with differences in the repair capacity of DNA damage and may thereby influence an individual's susceptibility to smoking‐related cancer. We investigated the association between the −93G→A polymorphism in the __hMLH1__ gene and the risk of lung cancer in a Korean population. The __hMLH1__ −93G→A polymorphism was typed in 372 lung cancer patients and 371 healthy controls that were frequency‐matched for age and sex. There was no significant association between the __hMLH1__ −93G→A genotype and the risk for adenocarcinoma or small cell carcinoma. However, the AA genotype was associated with a significantly increased risk for squamous cell carcinoma compared with both the GG genotype (adjusted OR = 2.02; 95% CI = 1.15–3.55; __p__ = 0.014) and the combined GG and GA genotype (adjusted OR = 1.83; 95% CI = 1.24–2.71; __p__ = 0.003). When the subjects were stratified by smoking exposure, the AA genotype was associated with a significantly increased risk for squamous cell carcinoma in lighter smokers (≤ 39 pack‐years; adjusted OR = 1.95; 95% CI = 1.03–3.66; __p__ = 0.039) compared with the combined GG and GA genotype, whereas t
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- Author
- Sun Ha Park; Ga Young Lee; Hyo‐Sung Jeon; Su Jeong Lee; Kyung Mee Kim; Sang Soo Jang; Chang Ho Kim; Won Kee Lee; Sin Kam; Rang Woon Park; In‐San Kim; Tae Hoon Jung; Jae Yong Park
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)